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Oligonucleotide Design Lead

Salario no especificado

Publicado 17 may 2026

GRUNENTHAL PHARMA, S,A,Madrid

Sobre este empleo

Lead the design and computational optimisation of RNA therapeutics, particularly siRNA, integrating RNA biology with oligonucleotide chemistry to enable gene knockdown and RNA regulatory approaches, including up-regulation strategies.
Define and prioritise target sites and design strategies by integrating sequence features, RNA accessibility, transcript structure, cross-species alignment, and emerging experimental data
Drive iterative design–test–learn cycles by analysing and rapidly integrating datasets linking sequence, chemistry, and biological activity to inform decision-making
Develop and apply computational tools and workflows (e.g. Python or R) to enable scalable oligonucleotide design, data integration, and rapid sequence–chemistry iteration
Partner closely with oligonucleotide chemists and delivery scientists to co-optimise sequence, chemical modifications, and delivery approaches to maximise potency, durability, and tissue activity
Lead and contribute to discovery programs advancing RNA therapeutic candidates toward candidate profiling and clinical development, while helping prioritise and evaluate new targets aligned with platform capabilities.

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42 684 €

42 684 €42 684 €

Basado en 1 006 ofertas con salario para Empleos en Madrid

GRUNENTHAL PHARMA, S,A, Madrid · 17 may 2026